| First Author | Lim WL | Year | 2013 |
| Journal | Neurobiol Aging | Volume | 34 |
| Issue | 9 | Pages | 2217-24 |
| PubMed ID | 23601809 | Mgi Jnum | J:211735 |
| Mgi Id | MGI:5576101 | Doi | 10.1016/j.neurobiolaging.2013.03.012 |
| Citation | Lim WL, et al. (2013) Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E epsilon3 and epsilon4 knock-in mice. Neurobiol Aging 34(9):2217-24 |
| abstractText | Apolipoprotein E (ApoE) is important in facilitating the transport of lipids (cholesterol, phospholipids, and sulfatides) and plays a fundamental role in normal lipid metabolism. High cholesterol levels increases the risk of developing Alzheimer's disease. In this study, we investigated the effects of a high-fat high cholesterol (HFHC) diet on brain lipid profiles in 95 young and aged APOE epsilon3 and epsilon4 knock-in mice to determine whether diet leads to altered brain levels of a number of glycerophospholipids, sphingolipids, cholesterol precursors, cholesterol, cholesterol oxidation products, and cholesterol esters. The results in this study revealed significant changes in lipid levels. The HFHC-enriched diet influenced the levels of cholesterol esters. A sharp increase in cholesterol ester levels, particularly in the aged APOE epsilon4 diet-enriched group, might be suggestive of abnormal acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT) activity and/or levels. Age exerts appreciable effects on the brain lipidome, especially with regard to polar lipid species. |
