| First Author | Kasai A | Year | 2022 |
| Journal | Am J Physiol Regul Integr Comp Physiol | Volume | 322 |
| Issue | 6 | Pages | R511-R525 |
| PubMed ID | 35318866 | Mgi Jnum | J:322492 |
| Mgi Id | MGI:7257898 | Doi | 10.1152/ajpregu.00304.2021 |
| Citation | Kasai A, et al. (2022) Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice. Am J Physiol Regul Integr Comp Physiol |
| abstractText | Aldehyde dehydrogenase 2 (ALDH2) detoxifies acetaldehyde produced from ethanol. A missense single nucleotide polymorphism (SNP) rs671 in ALDH2 exhibits a dominant-negative form of the ALDH2 protein. Nearly 40% of people in East Asia carry an inactive ALDH2*2 mutation. Previous studies reported that ALDH2*2 is associated with increased risk of several diseases. In this study, we examined the effect of ALDH2 deficiency on age-related muscle atrophy and its underlying mechanisms. We found that ALDH2 deficiency promotes age-related loss of muscle fiber cross-sectional areas, especially in oxidative fibers. Furthermore, ALDH2 deficiency exacerbated age-related accumulation of 4-hydroxy-2-nonenal (4-HNE), a marker of oxidative stress in the gastrocnemius muscle. Similarly, mitochondrial reactive oxygen species (ROS) production increased in aged ALDH2-knockout mice, indicating that ALDH2 deficiency induced mitochondrial dysfunction. In summary, ALDH2 deficiency promotes age-related muscle loss, especially in oxidative fibers, which may be associated with an increased accumulation of oxidative stress via mitochondrial dysfunction. |
