| First Author | Belbezier A | Year | 2024 |
| Journal | Front Immunol | Volume | 15 |
| Pages | 1393096 | PubMed ID | 38855101 |
| Mgi Jnum | J:354879 | Mgi Id | MGI:7658123 |
| Doi | 10.3389/fimmu.2024.1393096 | Citation | Belbezier A, et al. (2024) Interleukin-1 regulates follicular T cells during the germinal center reaction. Front Immunol 15:1393096 |
| abstractText | INTRODUCTION: Antibody production and the generation of memory B cells are regulated by T follicular helper (Tfh) and T follicular regulatory (Tfr) cells in germinal centers. However, the precise role of Tfr cells in controlling antibody production is still unclear. We have previously shown that both Tfh and Tfr cells express the IL-1R1 agonist receptor, whereas only Tfr cells express the IL-1R2 decoy and IL-1Ra antagonist receptors. We aimed to investigate the role of IL-1 receptors in the regulation of B cell responses by Tfh and Tfr. METHODS: We generated mice with IL-1 receptors inactivated in Tfh or Tfr and measured antibody production and cell activation after immunisation. RESULTS: While IL-1beta levels are increased in the draining lymph node after immunisation, antigen-specific antibody levels and cell phenotypes indicated that IL-1beta can activate both Tfh and Tfr cells through IL-1R1 stimulation. Surprisingly, expression of IL-1R2 and IL-1Ra on Tfr cells does not block IL-1 activation of Tfh cells, but rather prevents IL-1/IL-1R1-mediated early activation of Tfr cells. IL-1Rs also regulate the antibody response to autoantigens and its associated pathophysiology in an experimental lupus model. DISCUSSION: Collectively, our results show that IL-1 inhibitory receptors expressed by Tfr cells prevent their own activation and suppressive function, thus licensing IL-1-mediated activation of Tfh cells after immunisation. Further mechanistic studies should unravel these complex interactions between IL-1beta and follicular helper and regulatory T cells and provide new avenues for therapeutic intervention. |
