| First Author | Seré K | Year | 2012 |
| Journal | Immunity | Volume | 37 |
| Issue | 5 | Pages | 905-16 |
| PubMed ID | 23159228 | Mgi Jnum | J:190439 |
| Mgi Id | MGI:5448868 | Doi | 10.1016/j.immuni.2012.07.019 |
| Citation | Sere K, et al. (2012) Two distinct types of Langerhans cells populate the skin during steady state and inflammation. Immunity 37(5):905-16 |
| abstractText | Langerhans cells (LCs), the dendritic cells (DCs) in skin epidermis, possess an exceptional life cycle and developmental origin. Here we identified two types of LCs, short-term and long-term LCs, which transiently or stably reconstitute the LC compartment, respectively. Short-term LCs developed from Gr-1(hi) monocytes under inflammatory conditions and occurred independently of the transcription factor Id2. Long-term LCs arose from bone marrow in steady state and were critically dependent on Id2. Surface marker and gene expression analysis positioned short-term LCs close to Gr-1(hi) monocytes, which is indicative of their monocytic origin. We also show that LC reconstitution after UV light exposure occurs in two waves: an initial fast and transient wave of Gr-1(hi) monocyte-derived short-term LCs is followed by a second wave of steady-state precursor-derived long-term LCs. Our data demonstrate the presence of two types of LCs that develop through different pathways in inflammation and steady state. |
