| First Author | Zheng H | Year | 1995 |
| Journal | Immunity | Volume | 3 |
| Issue | 1 | Pages | 9-19 |
| PubMed ID | 7621081 | Mgi Jnum | J:27234 |
| Mgi Id | MGI:74651 | Doi | 10.1016/1074-7613(95)90154-x |
| Citation | Zheng H, et al. (1995) Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice. Immunity 3(1):9-19 |
| abstractText | We used gene targeting in embryonic stem cells to introduce an IL-1 beta null allele in mice. The IL-1 beta-deficient mice develop normally and are apparently healthy and fertile. The IL-1 beta null mice responded normally in models of contact and delayed-type hypersensitivity or following bacterial endotoxin LPS-induced inflammation. The IL-1 beta-deficient mice showed equivalent resistance to Listeria monocytogenes compared with wild-type controls. In contrast, when challenged with turpentine, which causes localized inflammation and tissue injury, the IL-1 beta mutant mice exhibited an impaired acute-phase inflammatory response and were completely resistant to fever development and anorexia. These results highlight a central role for IL-1 beta as a pyrogen and a mediator of the acute-phase response in a subset of inflammatory disease models, and support the notion that blocking the action of a single key cytokine can alter the course of specific immune and inflammatory responses. |
