| First Author | Mason JL | Year | 2001 |
| Journal | J Neurosci | Volume | 21 |
| Issue | 18 | Pages | 7046-52 |
| PubMed ID | 11549714 | Mgi Jnum | J:71534 |
| Mgi Id | MGI:2150276 | Doi | 10.1523/JNEUROSCI.21-18-07046.2001 |
| Citation | Mason JL, et al. (2001) Interleukin-1beta promotes repair of the CNS. J Neurosci 21(18):7046-52 |
| abstractText | Interleukin-1beta (IL-1beta) is a proinflammatory cytokine associated with the pathophysiology of demyelinating disorders such as multiple sclerosis and viral infections of the CNS. However, we demonstrate here that IL-1beta appears to promote remyelination in the adult CNS. In IL-1beta(-/-) mice, acute demyelination progressed similarly to wild-type mice and showed parallel mature oligodendrocyte depletion, microglia-macrophage accumulation, and the appearance of oligodendrocyte precursors. In contrast, IL-1beta(-/-) mice failed to remyelinate properly, and this appeared to correlate with a lack of insulin-like growth factor-1 (IGF-1) production by microglia-macrophages and astrocytes and to a profound delay of precursors to differentiate into mature oligodendrocytes. Thus, IL-1beta may be crucial to the repair of the CNS, presumably through the induction of astrocyte and microglia-macrophage-derived IGF-1. |
