| First Author | Shi Y | Year | 2007 |
| Journal | Nat Immunol | Volume | 8 |
| Issue | 8 | Pages | 817-24 |
| PubMed ID | 17618287 | Mgi Jnum | J:123410 |
| Mgi Id | MGI:3718274 | Doi | 10.1038/ni1489 |
| Citation | Shi Y, et al. (2007) Critical regulation of CD4(+) T cell survival and autoimmunity by beta-arrestin 1. Nat Immunol 8(8):817-24 |
| abstractText | CD4(+) T cells are important in adaptive immunity, but their dysregulation can cause autoimmunity. Here we demonstrate that the multifunctional adaptor protein beta-arrestin 1 positively regulated naive and activated CD4(+) T cell survival. We found enhanced expression of the proto-oncogene Bcl2 through beta-arrestin 1-dependent regulation of acetylation of histone H4 at the Bcl2 promoter. Mice deficient in the gene encoding beta-arrestin 1 (Arrb1) were much more resistant to experimental autoimmune encephalomyelitis, whereas overexpression of Arrb1 increased susceptibility to this disease. CD4(+) T cells from patients with multiple sclerosis had much higher Arrb1 expression, and 'knockdown' of Arrb1 by RNA-mediated interference in those cells increased apoptosis induced by cytokine withdrawal. Our data demonstrate that beta-arrestin 1 is critical for CD4(+) T cell survival and is a factor in susceptibility to autoimmunity. |
