| First Author | Wohler J | Year | 2009 |
| Journal | Mol Immunol | Volume | 46 |
| Issue | 11-12 | Pages | 2424-8 |
| PubMed ID | 19428111 | Mgi Jnum | J:149546 |
| Mgi Id | MGI:3848660 | Doi | 10.1016/j.molimm.2009.04.004 |
| Citation | Wohler J, et al. (2009) LFA-1 is critical for regulatory T cell homeostasis and function. Mol Immunol 46(11-12):2424-8 |
| abstractText | Cellular adhesion molecules involved in cell-to-cell mediated suppression by Tregs are not well characterized. We found that the majority of Tregs expressed LFA-1 but most strikingly that the frequency of Tregs in LFA-1(-/-) mice was significantly lower (approximately 50%) in the spleen, lymph nodes, and Peyer's patches compared to wild type controls. The reduction in LFA-1(-/-) Treg cells appears due in part to a reduced capacity of LFA-1(-/-) CD4(+)CD25(-) cells to be induced to become Tregs in the lymph nodes. Importantly, we found that LFA-1(-/-) Tregs fail to suppress T cell responses in vitro and have reduced function in vivo. Treg-mediated suppression does not depend on LFA-1 interactions with ICAM-1 on the surface of responder cells. Our data demonstrate that LFA-1 plays a critical role in regulatory T cell homeostasis and function. |
