| First Author | Nakagawa Y | Year | 1998 |
| Journal | Brain Res Mol Brain Res | Volume | 58 |
| Issue | 1-2 | Pages | 132-7 |
| PubMed ID | 9685612 | Mgi Jnum | J:49051 |
| Mgi Id | MGI:1276621 | Doi | 10.1016/s0169-328x(98)00119-3 |
| Citation | Nakagawa Y, et al. (1998) Increased expression of 3-hydroxyanthranilate 3,4-dioxygenase gene in brain of epilepsy-prone El mice. Brain Res Mol Brain Res 58(1-2):132-7 |
| abstractText | The El mouse is an established animal model for human epilepsy. We previously reported that the level of quinolinic acid (QUIN), an excitotoxin, was high in the brain of epilepsy-prone El mice and that the increased production of QUIN was secondary to an increased activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6) in the brains of these mice. In this study, we cloned and sequenced the cDNA for 3-HAO and showed that its expression in the brain of El mice was higher than that of control ddY mice. These results suggest that a genetic defect leading to derepression of the 3-MAO gene expression in the brain may be involved in the pathogenesis for the epileptic diseases of El mice. (C) 1998 Elsevier Science B.V. All rights reserved. |
