| First Author | Masuda Y | Year | 1996 |
| Journal | Biochem Biophys Res Commun | Volume | 223 |
| Issue | 1 | Pages | 60-3 |
| PubMed ID | 8660379 | Mgi Jnum | J:33499 |
| Mgi Id | MGI:80978 | Doi | 10.1006/bbrc.1996.0846 |
| Citation | Masuda Y, et al. (1996) Platelet-derived growth factor B-chain homodimer suppressing a convulsion of epilepsy model mouse El. Biochem Biophys Res Commun 223(1):60-3 |
| abstractText | El mouse is a mutant which has epileptic convulsions after tossing-up stimulations and has a hippocampal dysfunction. Platelet-derived growth factor B-chain homodimer has been reported to be a trophic factor of hippocampal neurons. We found that a recombinant PDGF-BB suppressed the convulsions of El mice in a dose-dependent manner. Furthermore, thrombin-treated mice manifested no convulsions, but thrombin receptor activating peptide-treated ones had convulsions. These findings suggest that an abnormality in PDGF-BB release may make El mice susceptible to tonic-clonic convulsions. |
