| First Author | Carter LL | Year | 1995 |
| Journal | J Immunol | Volume | 155 |
| Issue | 3 | Pages | 1028-31 |
| PubMed ID | 7543509 | Mgi Jnum | J:27184 |
| Mgi Id | MGI:74604 | Doi | 10.4049/jimmunol.155.3.1028 |
| Citation | Carter LL, et al. (1995) Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations. J Immunol 155(3):1028-31 |
| abstractText | IFN-gamma-secreting T1 and IL-5-secreting T2 subsets of CD8 effectors were generated in vitro using freshly isolated cells from wild-type and perforin knockout mice stimulated with allogeneic Ag-presenting cells. Both T1 and T2 effectors from wild-type mice exhibited perforin-mediated cytolysis. T1, but not T2, populations from perforin knockout mice displayed significant lysis by the Fas-mediated pathway. Th1 cells have recently been shown to be regulated by Fas and we speculate that Fas-mediated mechanisms are involved in the regulation of both Th1 and T1 populations of T cells. |
