| First Author | O'Keeffe M | Year | 2012 |
| Journal | J Immunol | Volume | 188 |
| Issue | 8 | Pages | 3774-83 |
| PubMed ID | 22422879 | Mgi Jnum | J:184068 |
| Mgi Id | MGI:5320222 | Doi | 10.4049/jimmunol.1101365 |
| Citation | O'Keeffe M, et al. (2012) Nonplasmacytoid, high IFN-alpha-producing, bone marrow dendritic cells. J Immunol 188(8):3774-83 |
| abstractText | Plasmacytoid dendritic cells (pDC) are the producers of type I IFNs in response to TLR9 ligands. However, we have found that when bone marrow is depleted of pDC, the IFN-alpha produced in response to TLR9 ligands is not fully removed. We assign the source of this non-pDC IFN-alpha as a newly described DC type. It displays the high IFN-alpha producing activity of pDC but to a more limited range of viruses. Unlike pDC, the novel DC display high T cell stimulation capacity. Moreover, unlike mouse pDC, they are matured with GM-CSF and are less prone to apoptosis upon activation stimuli, including viruses. We propose that these DC constitute a novel bone marrow inflammatory DC type, ideally geared to linking innate and adaptive immune responses in bone marrow via their potent IFN-alpha production and high T cell stimulatory capacity. |
