| First Author | Leonard JR | Year | 2001 |
| Journal | Brain Res Dev Brain Res | Volume | 128 |
| Issue | 2 | Pages | 187-90 |
| PubMed ID | 11412905 | Mgi Jnum | J:71150 |
| Mgi Id | MGI:2149239 | Doi | 10.1016/s0165-3806(01)00174-2 |
| Citation | Leonard JR, et al. (2001) Bid regulation of neuronal apoptosis. Brain Res Dev Brain Res 128(2):187-90 |
| abstractText | Bid is a BH3 domain only pro-apoptotic member of the Bcl-2 family which interacts with Bax to regulate apoptosis. Bax-deficient embryos show decreased neuronal programmed cell death in vivo and resistance to cytosine arabinoside (AraC)-induced neuronal apoptosis in vitro. In this report, we demonstrate that Bid-deficient embryos show no neurodevelopmental abnormalities, and Bid-deficiency has no effect on the in vitro apoptotic response of either telencephalic neural precursor cells or neurons to AraC-induced death. We conclude that bid does not play an essential role in either naturally occurring or genotoxin-induced neuronal cell death. |
