| First Author | Natsuume-Sakai S | Year | 1978 |
| Journal | J Immunol | Volume | 121 |
| Issue | 5 | Pages | 2025-9 |
| PubMed ID | 101594 | Mgi Jnum | J:6057 |
| Mgi Id | MGI:54534 | Doi | 10.4049/jimmunol.121.5.2025 |
| Citation | Natsuume-Sakai S, et al. (1978) Preparation of an alloantiserum to murine C3 and demonstration of multiple alleles. J Immunol 121(5):2025-9 |
| abstractText | An antiserum was produced in C3H/He mice that can recognize the antigenic variations of murine C3. The alloantiserum is directed to the gene product of one of the alleles (C3-1a allele) of the C3-1 locus that controls genetic variations of murine C3 and is linked to H-2. The antiserum formed a single precipitin line in the Ouchterlony test with sera obtained from mice that carry the C3-1a/a or C3-1a/b genotype, but it did not react with sera from mice that do not have C3 coded for by the C3-1a allele. By the use of the alloantiserum, we detected a new C3 allotype (C3-1 CC) in SWR/J mice. The C3-1 CC is distinct from the other two allotypes on the basis of antigenicity and isoelectric point (pI). Therefore, at least three alleles have been identified for the C3-1 locus. |
