Primary Identifier | MGI:2158693 | Allele Type | Targeted |
Attribute String | Null/knockout, Reporter | Gene | Sox9 |
Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A 300 bp DNA fragment containing part of exon 1 was replaced with an IRES-lacZ gene followed by a neomycin selection cassette. Northern blot and western blot analysis on chondrocytes derived from heterozygous mice demonstrated reduced expression of both the encoded transcript and protein. |