| First Author | Qiu H | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 1009 |
| PubMed ID | 32081882 | Mgi Jnum | J:287127 |
| Mgi Id | MGI:6401669 | Doi | 10.1038/s41467-020-14614-4 |
| Citation | Qiu H, et al. (2020) MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response. Nat Commun 11(1):1009 |
| abstractText | The MEN1 gene, a tumor suppressor gene that encodes the protein menin, is mutated at high frequencies in neuroendocrine (NE) tumors; however, the biological importance of this gene in NE-type lung cancer in vivo remains unclear. Here, we established an ATII-specific Kras(G12D/+)/Men1(-/-) driven genetically engineered mouse model and show that deficiency of menin results in the accumulation of DNA damage and antagonizes oncogenic Kras-induced senescence and the epithelial-to-mesenchymal transition during lung tumorigenesis. The loss of menin expression in certain human primary lung cancers correlates with elevated NE profiles and reduced overall survival. |
