| First Author | Sohn JH | Year | 2003 |
| Journal | Nat Med | Volume | 9 |
| Issue | 2 | Pages | 206-12 |
| PubMed ID | 12514742 | Mgi Jnum | J:81697 |
| Mgi Id | MGI:2449846 | Doi | 10.1038/nm814 |
| Citation | Sohn JH, et al. (2003) Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Nat Med 9(2):206-12 |
| abstractText | Systemic tolerance can be induced by the introduction of antigen into an immune-privileged site. Here we investigated the role of complement in the induction of tolerance after intraocular injection. We found that the development of antigen-specific tolerance is dependent on a complement activation product. The ligation of the complement C3 activation product iC3b to complement receptor type 3 (the iC3b receptor) on antigen-presenting cells resulted in the sequential production of transforming growth factor-beta2 and interleukin-10, which is essential for the induction of tolerance. These observations may extend to the development of both neonatal tolerance and other forms of acquired tolerance. |
