| Primary Identifier | MGI:2158728 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Tgfbr2 |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| description | Chimeric mice exhibit a wasting phenotype with severe weight loss within 2 weeks. Chimeras show various phenotypes, from small organ size, to cystic kidney and internal hydrcephalus with internal hemorrhage in the brain, or agnathia with anophthalmia and synotia (J:73414). |
| molecularNote | A neomycin selection cassette was inserted into exon 4 at the sequence corresponding to codon 230. RT-PCR analysis on RNA derived from targeted ES cells demonstrated that no wild-type transcript was produced from this allele. |
