| First Author | Shida N | Year | 1998 |
| Journal | Biochim Biophys Acta | Volume | 1407 |
| Issue | 1 | Pages | 79-83 |
| PubMed ID | 9639680 | Mgi Jnum | J:48743 |
| Mgi Id | MGI:1274941 | Doi | 10.1016/s0925-4439(98)00024-6 |
| Citation | Shida N, et al. (1998) Estrogen-induced tumorigenesis in the pituitary gland of TGF-beta(+/-) knockout mice. Biochim Biophys Acta 1407(1):79-83 |
| abstractText | Transforming growth factor (TGF)-beta receptor type II gene (Tgfbr2) knockout and wild type mice underwent chronic estrogen exposure using estradiol pellets. Histological examination of the pituitary glands found 38 adenomas in 14 Tgfbr2(+/-) mice but only one tumor in ten wild type mice. Pituitary tumorigenesis is greatly accelerated in Tgfbr2(+/-) mice by estrogen treatment. |
