| First Author | Lauer AM | Year | 2017 |
| Journal | Front Neurosci | Volume | 11 |
| Pages | 304 | PubMed ID | 28626386 |
| Mgi Jnum | J:276647 | Mgi Id | MGI:6307532 |
| Doi | 10.3389/fnins.2017.00304 | Citation | Lauer AM (2017) Minimal Effects of Age and Exposure to a Noisy Environment on Hearing in Alpha9 Nicotinic Receptor Knockout Mice. Front Neurosci 11:304 |
| abstractText | Studies have suggested a role of weakened medial olivocochlear (OC) efferent feedback in accelerated hearing loss and increased susceptibility to noise. The present study investigated the progression of hearing loss with age and exposure to a noisy environment in medial OC-deficient mice. Alpha9 nicotinic acetylcholine receptor knockout (alpha9KO) and wild types were screened for hearing loss using auditory brainstem responses. alpha9KO mice housed in a quiet environment did not show increased hearing loss compared to wild types in young adulthood and middle age. Challenging the medial OC system by housing in a noisy environment did not increase hearing loss in alpha9KO mice compared to wild types. ABR wave 1 amplitudes also did not show differences between alpha9KO mice and wild types. These data suggest that deficient medial OC feedback does not result in early onset of hearing loss. |
