| First Author | Kuida K | Year | 1995 |
| Journal | Science | Volume | 267 |
| Issue | 5206 | Pages | 2000-3 |
| PubMed ID | 7535475 | Mgi Jnum | J:24258 |
| Mgi Id | MGI:72007 | Doi | 10.1126/science.7535475 |
| Citation | Kuida K, et al. (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267(5206):2000-3 |
| abstractText | The interleukin-1 beta (IL-1 beta) converting enzyme (ICE) processes the inactive IL-1 beta precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene (ICE-/-) did not export IL-1 beta or interleukin-1 alpha (IL-1 alpha) after stimulation with lipopolysaccharide. Export of tumor necrosis factor-alpha and interleukin-6 (IL-6) from these cells was also diminished. Thymocytes from ICE-/- mice were sensitive to apoptosis induced by dexamethasone or ionizing radiation, but were resistant to apoptosis induced by Fas antibody. Despite this defect in apoptosis, ICE-/- mice proceed normally through development. |
