| First Author | Zanoni I | Year | 2016 |
| Journal | Science | Volume | 352 |
| Issue | 6290 | Pages | 1232-6 |
| PubMed ID | 27103670 | Mgi Jnum | J:232572 |
| Mgi Id | MGI:5779585 | Doi | 10.1126/science.aaf3036 |
| Citation | Zanoni I, et al. (2016) An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science 352(6290):1232-6 |
| abstractText | Dendritic cells (DCs) use pattern recognition receptors to detect microorganisms and activate protective immunity. These cells and receptors are thought to operate in an all-or-nothing manner, existing in an immunologically active or inactive state. Here, we report that encounters with microbial products and self-encoded oxidized phospholipids (oxPAPC) induce an enhanced DC activation state, which we call "hyperactive." Hyperactive DCs induce potent adaptive immune responses and are elicited by caspase-11, an enzyme that binds oxPAPC and bacterial lipopolysaccharide (LPS). oxPAPC and LPS bind caspase-11 via distinct domains and elicit different inflammasome-dependent activities. Both lipids induce caspase-11-dependent interleukin-1 release, but only LPS induces pyroptosis. The cells and receptors of the innate immune system can therefore achieve different activation states, which may permit context-dependent responses to infection. |
