| First Author | Matter M | Year | 2007 |
| Journal | Cancer Res | Volume | 67 |
| Issue | 15 | Pages | 7467-76 |
| PubMed ID | 17671217 | Mgi Jnum | J:123912 |
| Mgi Id | MGI:3719957 | Doi | 10.1158/0008-5472.CAN-06-4372 |
| Citation | Matter M, et al. (2007) Decreased tumor surveillance after adoptive T-cell therapy. Cancer Res 67(15):7467-76 |
| abstractText | The effect of cancer immunotherapy on the endogenous immune response against tumors is largely unknown. Therefore, we studied immune responses against murine tumors expressing the glycoprotein (GP) and/or nucleoprotein of lymphocytic choriomeningitis virus (LCMV) with or without adoptive T-cell therapy. In nontreated animals, CTLs specific for different epitopes as well as LCMV-GP-specific antibodies contributed to tumor surveillance. Adoptive immunotherapy with monoclonal CTLs specific for LCMV-gp33 impaired the endogenous tumor-specific antibody and CTL response by targeting antigen cross-presenting cells. As a consequence and in contrast to expectations, immunotherapy enhanced tumor growth. Thus, for certain immunogenic tumors, a reduction of tumor-specific B- and T-cell responses and enhanced tumor growth may be an unwanted consequence of adoptive immunotherapy. |
