| First Author | Gao N | Year | 2006 |
| Journal | J Immunol | Volume | 176 |
| Issue | 5 | Pages | 2758-64 |
| PubMed ID | 16493031 | Mgi Jnum | J:129400 |
| Mgi Id | MGI:3769205 | Doi | 10.4049/jimmunol.176.5.2758 |
| Citation | Gao N, et al. (2006) B cell induction of IL-13 expression in NK cells: role of CD244 and SLAM-associated protein. J Immunol 176(5):2758-64 |
| abstractText | NK cells are an important component of the innate immune system that can also interact with B cells in a mutually productive manner. We have previously shown that activated B cells can induce NK cells to up-regulate their secretion of IFN-gamma. In this study, we show that B cells, and, particularly, marginal zone B cells, can, in addition, induce NK cells via direct cell-cell interactions to express mRNA encoding the Th2 cytokine IL-13. The induction of NK cell IL-13 mRNA expression requires the ligation of the CD244 receptor by the CD48 ligand on B cells via signaling pathways that depend upon expression of the X-linked lymphoproliferative disease gene product, SH2D1A/DSHP/SAP (SLAM-associated protein, or SAP) in NK cells. Thus, the positive signals attributed to the B cell activation of CD244 on murine NK cells appears to be more similar to the activity of CD244 on human cells. The induction of IL-13 mRNA by B cells may account for the effect of NK cells on the generation of Th2-type responses in the presence of some adjuvants. |
