| First Author | Rumble JM | Year | 2008 |
| Journal | Biochem J | Volume | 415 |
| Issue | 1 | Pages | 21-5 |
| PubMed ID | 18684108 | Mgi Jnum | J:140404 |
| Mgi Id | MGI:3813748 | Doi | 10.1042/BJ20081188 |
| Citation | Rumble JM, et al. (2008) Apoptotic sensitivity of murine IAP-deficient cells. Biochem J 415(1):21-5 |
| abstractText | Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli. |
