| First Author | Serbina NV | Year | 2003 |
| Journal | Immunity | Volume | 19 |
| Issue | 1 | Pages | 59-70 |
| PubMed ID | 12871639 | Mgi Jnum | J:291264 |
| Mgi Id | MGI:6435872 | Doi | 10.1016/s1074-7613(03)00171-7 |
| Citation | Serbina NV, et al. (2003) TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 19(1):59-70 |
| abstractText | Dendritic cells (DCs) present microbial antigens to T cells and provide inflammatory signals that modulate T cell differentiation. While the role of DCs in adaptive immunity is well established, their involvement in innate immune defenses is less well defined. We have identified a TNF/iNOS-producing (Tip)-DC subset in spleens of Listeria monocytogenes-infected mice that is absent from CCR2-deficient mice. The absence of Tip-DCs results in profound TNF and iNOS deficiencies and an inability to clear primary bacterial infection. CD8 and CD4 T cell responses to L. monocytogenes antigens are preserved in CCR2-deficient mice, indicating that Tip-DCs are not essential for T cell priming. Tip-DCs, as the predominant source of TNF and iNOS during L. monocytogenes infection, orchestrate and mediate innate immune defense against this intracellular bacterial pathogen. |
