| First Author | Schilling M | Year | 2009 |
| Journal | Exp Neurol | Volume | 219 |
| Issue | 2 | Pages | 583-5 |
| PubMed ID | 19615366 | Mgi Jnum | J:154877 |
| Mgi Id | MGI:4410410 | Doi | 10.1016/j.expneurol.2009.07.003 |
| Citation | Schilling M, et al. (2009) Turn-over of meningeal and perivascular macrophages in the brain of MCP-1-, CCR-2- or double knockout mice. Exp Neurol 219(2):583-5 |
| abstractText | Perivascular and meningeal macrophages are important for immune surveillance in the healthy and the injured brain. Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage migration and permeability of the blood brain barrier. In the present study, we investigated the influence of MCP-1 or/and chemokine receptor 2 (CCR2)-deficiency on macrophage turnover. The results showed no influence of single MCP-1- or CCR-2-deficiency, but double-deficient mice revealed a virtual absence of blood-borne macrophage recruitment. This finding emphasizes that the MCP-1/CCR2 axis is crucially important for macrophage turnover and compensatory mechanisms remain only partially sufficient to sustain regulatory functions. |
