| First Author | Picker JD | Year | 2006 |
| Journal | Neuroreport | Volume | 17 |
| Issue | 5 | Pages | 541-4 |
| PubMed ID | 16543822 | Mgi Jnum | J:107578 |
| Mgi Id | MGI:3621502 | Doi | 10.1097/01.wnr.0000208995.38695.2f |
| Citation | Picker JD, et al. (2006) An altered neonatal behavioral phenotype in Mecp2 mutant mice. Neuroreport 17(5):541-4 |
| abstractText | We examined somatic growth, somatosensory reflexes, and ultrasonic calls from postnatal day 3 to day 18 in Mecp2 mutant mice, a mouse model of Rett syndrome. Both Mecp2 null male and Mecp2 heterozygous female mice exhibited normal somatic growth, but transient delays in the development of some reflexes relative to sex-matched wild-type mice. Both Mecp2 null male and heterozygous female mice exhibited dramatic increases in ultrasonic vocalizations in response to social isolation; these differences were evident as early as postnatal day 5. These results suggest very early abnormalities in sensory reflex development and behavioral responsiveness in the Mecp2 mutants that may provide a target for early therapeutic intervention. |
