| First Author | Farhoomand F | Year | 2023 |
| Journal | Somatosens Mot Res | Volume | 40 |
| Issue | 4 | Pages | 133-140 |
| PubMed ID | 36565289 | Mgi Jnum | J:349315 |
| Mgi Id | MGI:7640378 | Doi | 10.1080/08990220.2022.2158799 |
| Citation | Farhoomand F, et al. (2023) Long-term cortical plasticity following sensory deprivation is reduced in male Rett model mice. Somatosens Mot Res 40(4):133-140 |
| abstractText | PURPOSE/AIM: Rett (RTT) syndrome, a neurodevelopmental disorder, results from loss-of-function mutations in methyl-CpG-binding protein 2. We studied activity-dependent plasticity induced by sensory deprivation via whisker trimming in early symptomatic male mutant mice to assess neural rewiring capability. METHODS: One whisker was trimmed for 0-14 days and intrinsic optical imaging of the transient reduction of brain blood oxygenation resulting from neural activation by 1 second of wiggling of the whisker stump was compared to that of an untrimmed control whisker. RESULTS: Cortical evoked responses to wiggling a non-trimmed whisker were constant for 14 days, reduced for a trimmed whisker by 49.0 +/- 4.3% in wild type (n = 14) but by only 22.7 +/- 4.6% in mutant (n = 18, p = 0.001). CONCLUSION: As the reduction in neural activation following sensory deprivation in whisker barrel cortex is known to be dependent upon evoked and basal neural activity, impairment of cortical re-wiring following whisker trimming provides a paradigm suitable to explore mechanisms underlying deficiencies in the establishment and maintenance of synapses in RTT, which can be potentially targeted by therapeutics. |
