Primary Identifier | MGI:2158363 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Zmpste24 |
Transmission | Germline | Strain of Origin | 129S4/SvJae |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A genomic fragment containing exon 8 was replaced with a floxed neomycin selection cassette. Enzymatic activity assays on liver cell membranes derived from homozygous mice demonstrated reduced or absent processing of synthetic substrates, suggesting that no functional protein is produced from this allele. |