| First Author | Bonnefont J | Year | 2019 |
| Journal | Neuron | Volume | 103 |
| Issue | 6 | Pages | 1096-1108.e4 |
| PubMed ID | 31353074 | Mgi Jnum | J:283593 |
| Mgi Id | MGI:6381715 | Doi | 10.1016/j.neuron.2019.06.027 |
| Citation | Bonnefont J, et al. (2019) Cortical Neurogenesis Requires Bcl6-Mediated Transcriptional Repression of Multiple Self-Renewal-Promoting Extrinsic Pathways. Neuron 103(6):1096-1108.e4 |
| abstractText | During neurogenesis, progenitors switch from self-renewal to differentiation through the interplay of intrinsic and extrinsic cues, but how these are integrated remains poorly understood. Here, we combine whole-genome transcriptional and epigenetic analyses with in vivo functional studies to demonstrate that Bcl6, a transcriptional repressor previously reported to promote cortical neurogenesis, acts as a driver of the neurogenic transition through direct silencing of a selective repertoire of genes belonging to multiple extrinsic pathways promoting self-renewal, most strikingly the Wnt pathway. At the molecular level, Bcl6 represses its targets through Sirt1 recruitment followed by histone deacetylation. Our data identify a molecular logic by which a single cell-intrinsic factor represses multiple extrinsic pathways that favor self-renewal, thereby ensuring robustness of neuronal fate transition. |
