| First Author | Yun SJ | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 4 | Pages | 685-90 |
| PubMed ID | 19166849 | Mgi Jnum | J:146145 |
| Mgi Id | MGI:3836830 | Doi | 10.1016/j.febslet.2009.01.005 |
| Citation | Yun SJ, et al. (2009) Differential regulation of Akt/protein kinase B isoforms during cell cycle progression. FEBS Lett 583(4):685-90 |
| abstractText | Phosphatidylinositol 3-kinase pathways play key regulatory roles in cell cycle progression into S phase. In this study, we demonstrated that Akt1/PKBalpha isoform plays an essential role in G(1)/S transition and proliferation. Cells lacking Akt1/PKBalpha showed an attenuated proliferation as well as G(1)/S transition, whereas cells lacking Akt2/PKBbeta showed normal proliferation and G(1)/S transition. The effect of Akt1/PKBalpha on cell proliferation and G(1)/S transition was completely abolished by swapping pleckstrin homology (PH) domain with that of Akt2/PKBbeta. Finally, full activation of Akt/PKB and cyclin D expression was achieved by the Akt1/PKBalpha or chimeric proteins containing the PH domain of Akt1/PKBalpha indicating that the PH domain of Akt1/PKBalpha provides full kinase activity and is necessary for the G(1)/S transition. |
