| First Author | Gu WX | Year | 2010 |
| Journal | Dev Dyn | Volume | 239 |
| Issue | 8 | Pages | 2246-55 |
| PubMed ID | 20589901 | Mgi Jnum | J:161785 |
| Mgi Id | MGI:4461341 | Doi | 10.1002/dvdy.22357 |
| Citation | Gu WX, et al. (2010) Identification of genes controlled by LMX1B in E13.5 mouse limbs. Dev Dyn 239(8):2246-55 |
| abstractText | During limb development, the dorsal limb mesenchyme expression of the transcription factor LMX1B is required for dorsoventral limb patterning. In mice, Lmx1b mutations result in the mirror-image duplication of ventral limb structures and loss of dorsal limb structures. Heterozygous LMX1B mutations in humans cause the Nail-Patella Syndrome characterized by limb, kidney, and eye developmental defects. We used DNA microarrays to compare the mRNAs in E13.5 mouse Lmx1b mutant and wild-type limbs. We report 14 genes that require Lmx1b for their normal expression in the dorsal limb or the restriction of their expression to the ventral limb. |
