| First Author | Zhao Y | Year | 2014 |
| Journal | Biochem Biophys Res Commun | Volume | 450 |
| Issue | 1 | Pages | 526-31 |
| PubMed ID | 24924627 | Mgi Jnum | J:219442 |
| Mgi Id | MGI:5620838 | Doi | 10.1016/j.bbrc.2014.06.010 |
| Citation | Zhao Y, et al. (2014) TCR-induced, PKC-theta-mediated NF-kappaB activation is regulated by a caspase-8-caspase-9-caspase-3 cascade. Biochem Biophys Res Commun 450(1):526-31 |
| abstractText | It has been documented that caspase-8, a central player in apoptosis, is also crucial for TCR-mediated NF-kappaB activation. However, whether other caspases are also involved this process is unknown. In this report, we showed that in addition to caspase-8, caspase-9 is required for TCR-mediated NF-kappaB activation. Caspase-9 induces activation of PKC-theta, phosphorylation of Bcl10 and NF-kappaB activation in a caspase-3-dependent manner, but it appears that Bcl10 phosphorylation is uncoupled from NF-kappaB activation. Furthermore, caspase-8 lies upstream of caspase-9 during T cell activation. Therefore, TCR ligation elicits a caspase cascade involving caspase-8, caspase-9 and caspase-3 which initiates PKC-theta-dependent pathway leading to NF-kappaB activation and PKC-theta-independent Bcl10 phosphorylation which limits NF-kB activity. |
