| Primary Identifier | MGI:2158761 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Plg |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| description | Homozygous mutant mice survive embryonic development, but after birth show retarded growth and reduced fertility and survival. Impaired thrombolysis and fibrin deposition are observed. The symptoms resemble those following loss of both tissue and urokinase plasminogen activation (J:30174). Treatment of null mutant mice with exogenous plasminogen restores thrombolysis (J:34531). Ligneous conjunctivitis (OMIM 217090) has also been ascribed to PLG mutations (J:48307). |
| molecularNote | A neomycin selection cassette replaced a genomic fragment containing exons 15-17 which encodes part of the catalytic domain. Northern blot analysis on RNA derived from liver of homozygous mice demonstrated that no detectable transcript was produced from this allele. ELISA assays on plasma derived from homozygous mice confirmed that no active protein was detectable. |
