| First Author | Kondo S | Year | 2010 |
| Journal | Eur J Immunol | Volume | 40 |
| Issue | 5 | Pages | 1296-302 |
| PubMed ID | 20186877 | Mgi Jnum | J:160958 |
| Mgi Id | MGI:4456348 | Doi | 10.1002/eji.200939743 |
| Citation | Kondo S, et al. (2010) Regulatory role of leukocyte-common-antigen-related molecule (LAR) in thymocyte differentiation. Eur J Immunol 40(5):1296-302 |
| abstractText | The strength of interaction between the antigenic peptide-loaded MHC (MHC/p) and the TCR determines T-cell fate in the thymus. A high avidity interaction between the TCR and the MHC/p induces apoptosis of self-reactive T cells (negative selection), whereas a moderate avidity interaction rescues thymocytes from apoptosis and permits further differentiation to mature T cells (positive selection). Leukocyte common antigen-related molecule (LAR), a receptor-like protein tyrosine phosphatase, is expressed on immature thymocytes, but its role in thymocyte differentiation has not yet been fully elucidated. We analyzed LAR-deficient mice and demonstrated that LAR deficiency affected the differentiation and expansion of immature thymocytes as well as positive and negative selection. Furthermore, LAR deficiency resulted in a lower Ca2+ response. The results indicate that LAR is an important modulator of TCR signaling that controls thymocyte differentiation. |
