| First Author | Weinhold B | Year | 1997 |
| Journal | Biochem J | Volume | 327 ( Pt 2) |
| Pages | 425-9 | PubMed ID | 9359411 |
| Mgi Jnum | J:91342 | Mgi Id | MGI:3046586 |
| Doi | 10.1042/bj3270425 | Citation | Weinhold B, et al. (1997) Interleukin-6-dependent and -independent regulation of the human C-reactive protein gene. Biochem J 327(Pt 2):425-9 |
| abstractText | We have investigated the function of different mediators of the regulation of the human C-reactive protein (hCRP) gene in transgenic mice. hCRP was induced by lipopolysaccharide and wounding in interleukin-6 (IL-6) +/+ mice, but not in IL-6 -/- mice. This finding suggested that IL-6 is necessary for the induction of hCRP. However, injection of IL-6 did not induce the hCRP gene. Thus, the induction of hCRP by IL-6 seems to require an additional cofactor. Therefore, we screened different cytokines for their activity in IL-6 +/+ and IL-6 -/- mice. Surprisingly, interleukin-1beta, as well as oncostatin M or leukaemia inhibitory factor, led to an induction of hCRP in both genetic backgrounds. These results indicate an IL-6-dependent and -independent regulation of hCRP. These hCRP transgenic mice therefore represent a novel model system for defining the cytokine network involved in the regulation of acute-phase genes during the course of inflammation. |
