| First Author | Weinhold B | Year | 1997 |
| Journal | Biochem J | Volume | 325 ( Pt 3) |
| Pages | 617-21 | PubMed ID | 9271080 |
| Mgi Jnum | J:327633 | Mgi Id | MGI:7333242 |
| Doi | 10.1042/bj3250617 | Citation | Weinhold B, et al. (1997) Interleukin-6 is necessary, but not sufficient, for induction of the humanC-reactive protein gene in vivo. Biochem J 325 ( Pt 3):617-21 |
| abstractText | We have investigated the involvement of interleukin-6 (IL-6) in the induction of the gene encoding the acute-phase protein human C-reactive protein (hCRP). In transgenic mice the hCRP gene can be induced by lipopolysaccharide (LPS), but not by IL-6. In contrast, hCRP was inducible by IL-6 in primary human hepatocytes and in primary hepatocytes isolated from transgenic mice. To further evaluate the role of IL-6, we introduced the hCRP transgene into animals lacking endogenous IL-6 (IL-6-negative mice). Here, hCRP was not inducible by LPS, but was induced by a combination of LPS and IL-6. These results clearly demonstrate that IL-6 is necessary, but not sufficient, for the induction of hCRP expression. These animal models will allow further dissection of the cytokine network responsible for the regulation of the major human acute-phase reactant CRP. |
