| First Author | Sassone-Corsi P | Year | 2000 |
| Journal | Mol Reprod Dev | Volume | 56 |
| Issue | 2 Suppl | Pages | 228-9 |
| PubMed ID | 10824972 | Mgi Jnum | J:62415 |
| Mgi Id | MGI:1858854 | Doi | 10.1002/(SICI)1098-2795(200006)56:2+<228::AID-MRD2>3.0.CO;2-B |
| Citation | Sassone-Corsi P (2000) CREM: a master-switch regulating the balance between differentiation and apoptosis in male germ cells. Mol Reprod Dev 56(2 Suppl):228-9 |
| abstractText | Cyclic AMP-responsive element modulator (CREM) is a transcription factor highly expressed in the post-meiotic germ cells of the testis. Its pivotal role is to regulate the expression of several germ cell-specific genes, a crucial function as demonstrated by the severe phenotype of mice whose CREM gene was mutated by homologous recombination. CREM-deficient male animals are sterile and display a ten-fold increase in the apoptosis of germ cells. Recent results have shown that CREM needs a tissue-specific co-activator, ACT (activator of CREM in testis) to elicit its regulatory function in testis. |
