| First Author | Servillo G | Year | 1998 |
| Journal | Genes Dev | Volume | 12 |
| Issue | 23 | Pages | 3639-43 |
| PubMed ID | 9851970 | Mgi Jnum | J:81370 |
| Mgi Id | MGI:2449219 | Doi | 10.1101/gad.12.23.3639 |
| Citation | Servillo G, et al. (1998) Transcription factor CREM coordinates the timing of hepatocyte proliferation in the regenerating liver. Genes Dev 12(23):3639-43 |
| abstractText | The liver regenerates upon partial hepatectomy (PH) as terminally differentiated hepatocytes undergo a tremendous proliferative process. CREM gene expression is powerfully induced during liver regeneration. We show that cell proliferation is significantly reduced upon PH in CREM-/- mice. There is a reduction in DNA synthesis, in the number of mitosis and of phosphorylated histone H3-positive cells. The post-PH proliferation peak is delayed by 10 hr, indicating an altered hepatocyte cell cycle. Expression of cyclins A, B, D1, E, and cdc2, of c-fos and tyrosine aminotransferase is deregulated. CREM mutation results in delayed S-phase entry, impairing the synchronization of proliferation. |
