| First Author | Feuermann Y | Year | 2014 |
| Journal | PLoS One | Volume | 9 |
| Issue | 1 | Pages | e85123 |
| PubMed ID | 24497923 | Mgi Jnum | J:212687 |
| Mgi Id | MGI:5581987 | Doi | 10.1371/journal.pone.0085123 |
| Citation | Feuermann Y, et al. (2014) MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation. PLoS One 9(1):e85123 |
| abstractText | Development of mammary alveolar epithelium during pregnancy is controlled by prolactin, through the transcription factors STAT5A/B that activate specific sets of target genes. Here we asked whether some of STAT5's functions are mediated by microRNAs. The miR-21 promoter sequence contains a bona-fide STAT5 binding site and miR-21 levels increased in HC11 mammary cells upon prolactin treatment. In vivo miR-21 was abundantly expressed in mammary epithelium at day 6 of pregnancy. Analysis of mice lacking miR-21 revealed that their mammary tissue developed normally during pregnancy and dams were able to nurse their pups. Our study demonstrated that although expression of miR-21 is under prolactin control through the transcription factors STAT5A/B its presence is dispensable for mammary development and lactation. |
