| First Author | Feuermann Y | Year | 2012 |
| Journal | Genesis | Volume | 50 |
| Issue | 9 | Pages | 665-71 |
| PubMed ID | 22389215 | Mgi Jnum | J:187861 |
| Mgi Id | MGI:5438462 | Doi | 10.1002/dvg.22023 |
| Citation | Feuermann Y, et al. (2012) The miR-17/92 cluster is targeted by STAT5 but dispensable for mammary development. Genesis 50(9):665-71 |
| abstractText | Genome wide analysis revealed the miR-17/92 cluster as a STAT5 target. This cluster encodes six microRNAs, which predictably target genes that play a role in mammary gland development. In this study, we have deleted the miR-17/92 cluster in mammary stem cells and evaluated in the mouse its function during mammary gland development. Loss of the miR-17/92 cluster did not affect mammary development from prepuberty to lactation. Our studies demonstrated that, while expression of the miR-17/92 cluster is under control of the key mammary transcription factor STAT5, its presence is not required for normal mammary development or lactation. genesis 50:665-671, 2012. (c) 2012 Wiley Periodicals, Inc. |
