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Publication : ERK signaling expands mammalian cortical radial glial cells and extends the neurogenic period.

First Author  Sun M Year  2024
Journal  Proc Natl Acad Sci U S A Volume  121
Issue  13 Pages  e2314802121
PubMed ID  38498715 Mgi Jnum  J:354182
Mgi Id  MGI:7719825 Doi  10.1073/pnas.2314802121
Citation  Sun M, et al. (2024) ERK signaling expands mammalian cortical radial glial cells and extends the neurogenic period. Proc Natl Acad Sci U S A 121(13):e2314802121
abstractText  The molecular basis for cortical expansion during evolution remains largely unknown. Here, we report that fibroblast growth factor (FGF)-extracellular signal-regulated kinase (ERK) signaling promotes the self-renewal and expansion of cortical radial glial (RG) cells. Furthermore, FGF-ERK signaling induces bone morphogenic protein 7 (Bmp7) expression in cortical RG cells, which increases the length of the neurogenic period. We demonstrate that ERK signaling and Sonic Hedgehog (SHH) signaling mutually inhibit each other in cortical RG cells. We provide evidence that ERK signaling is elevated in cortical RG cells during development and evolution. We propose that the expansion of the mammalian cortex, notably in human, is driven by the ERK-BMP7-GLI3R signaling pathway in cortical RG cells, which participates in a positive feedback loop through antagonizing SHH signaling. We also propose that the relatively short cortical neurogenic period in mice is partly due to mouse cortical RG cells receiving higher SHH signaling that antagonizes ERK signaling.
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