|  Help  |  About  |  Contact Us

Publication : Hedgehog signaling is required for endometrial remodeling and myometrial homeostasis in the cycling mouse uterus.

First Author  Roberson EC Year  2023
Journal  iScience Volume  26
Issue  10 Pages  107993
PubMed ID  37810243 Mgi Jnum  J:342522
Mgi Id  MGI:7540212 Doi  10.1016/j.isci.2023.107993
Citation  Roberson EC, et al. (2023) Hedgehog signaling is required for endometrial remodeling and myometrial homeostasis in the cycling mouse uterus. iScience 26(10):107993
abstractText  Decades of work demonstrate that the mammalian estrous cycle is controlled by cycling steroid hormones. However, the signaling mechanisms that act downstream, linking hormonal action to the physical remodeling of the cycling uterus, remain unclear. To address this issue, we analyzed gene expression at all stages of the mouse estrous cycle. Strikingly, we found that several genetic programs well-known to control tissue morphogenesis in developing embryos displayed cyclical patterns of expression. We find that most of the genetic architectures of Hedgehog signaling (ligands, receptors, effectors, and transcription factors) are transcribed cyclically in the uterus, and that conditional disruption of the Hedgehog receptor smoothened not only elicits a failure of normal cyclical thickening of the endometrial lining but also induces aberrant deformation of the uterine smooth muscle. Together, our data shed light on the mechanisms underlying normal uterine remodeling specifically and cyclical gene expression generally.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

8 Bio Entities

Trail: Publication

0 Expression