| First Author | Hultgren O | Year | 1999 |
| Journal | Eur J Immunol | Volume | 29 |
| Issue | 8 | Pages | 2400-5 |
| PubMed ID | 10458752 | Mgi Jnum | J:115323 |
| Mgi Id | MGI:3691387 | Doi | 10.1002/(SICI)1521-4141(199908)29:08<2400::AID-IMMU2400>3.0.CO;2-E |
| Citation | Hultgren O, et al. (1999) Outcome of Staphylococcus aureus-triggered sepsis and arthritis in IL-4-deficient mice depends on the genetic background of the host. Eur J Immunol 29(8):2400-5 |
| abstractText | Disruption of the IL-4 gene in two inbred mouse strains revealed a dual role of IL-4 in Staphylococcus aureus sepsis and arthritis depending on the host's genetic background. IL-4 was protective in 129SV mice, since 5 days after S. aureus inoculation IL-4(-/-) mice displayed 70% mortality as compared to survival of all 129SV wild-type counterparts. On the other hand, IL-4 was detrimental in C57BL/6 mice, since survival of IL-4(-/-) C57BL/6 mice was increased, as compared to wild-type controls, due to decreased staphylococcal growth. Altogether, our results show the dual role of IL-4 in S. aureus sepsis and arthritis, depending on the genetic background of the host. |
