| First Author | Kanagawa O | Year | 1993 |
| Journal | Science | Volume | 262 |
| Issue | 5131 | Pages | 240-2 |
| PubMed ID | 8211142 | Mgi Jnum | J:15114 |
| Mgi Id | MGI:63251 | Doi | 10.1126/science.8211142 |
| Citation | Kanagawa O, et al. (1993) Resistance of mice deficient in IL-4 to retrovirus-induced immunodeficiency syndrome (MAIDS) [see comments]. Science 262(5131):240-2 |
| abstractText | The murine acquired immunodeficiency syndrome (MAIDS) is induced by a defective murine leukemia virus and has many symptoms similar to those found in patients infected with the human immunodeficiency virus. The presence of both B cells and CD4+ T cells is critical for the development of the disease. Furthermore, a Th2 cytokine response dominates during the progression of the disease. When interleukin-4 (IL-4)-deficient mice that are defective in Th2 cytokine responses were infected, there was no lethality, and the development of the T cell abnormalities associated with MAIDS was delayed. These data suggest that IL-4 or a Th2 response is involved in the development of retrovirus-induced immunodeficiency in mice. |
