| First Author | Brunet LR | Year | 1999 |
| Journal | J Parasitol | Volume | 85 |
| Issue | 4 | Pages | 734-6 |
| PubMed ID | 10461958 | Mgi Jnum | J:57428 |
| Mgi Id | MGI:1344571 | Citation | Brunet LR, et al. (1999) Schistosoma mansoni: IL-4 is necessary for concomitant immunity in mice. J Parasitol 85(4):734-6 |
| abstractText | To ask whether type-2 immune responses serve an essential role in concomitant immunity, that is the prevention of superinfection with Schistosoma mansoni, we compared resistance to a challenge infection in infected wild-type (WT) mice and in infected IL-4-/- mice, which are unable to mount Th2 responses during schistosomiasis. Although WT mice are protected from superinfection, resistance is abrogated in the absence of interleukin (n)-4. We conclude that IL-4 or IL-4-dependent responses, or both, an necessary for resistance to S. Mansoni superinfection in mice. |
