| Primary Identifier | MGI:2159246 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Vax2 |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
| Is Recombinase | false | Is Wild Type | false |
| description | Vax2 heterozygotes are fertile, viable and inditiguishable from wild-type. The homozygous mutant embryo shows incomplete closure of the optic fissure leading to coloboma and abnormal projection of the retinal ganglions. Teh mutant was carried on both a mixed 129/CD1 and a mixed 129/C57Bl6 background. |
| molecularNote | A PGK-neomycin cassette replaced the second exon, which encodes the first two helices and part of the third helix of the homeodomain. Gene targeting was confirmed by RT-PCR analysis. |
