| First Author | Rinkenberger JL | Year | 2000 |
| Journal | Genes Dev | Volume | 14 |
| Issue | 1 | Pages | 23-7 |
| PubMed ID | 10640272 | Mgi Jnum | J:59429 |
| Mgi Id | MGI:1351568 | Doi | 10.1101/gad.14.1.23 |
| Citation | Rinkenberger JL, et al. (2000) Mcl-1 deficiency results in peri-implantation embryonic lethality. Genes Dev 14(1):23-7 |
| abstractText | We disrupted the Mcl-1 locus in murine ES cells to determine the developmental roles of this Bcl-2 family member. Deletion of Mcl-1 resulted in peri-implantation embryonic lethality. Mcl-1(-/-) embryos do not implant in utero, but could be recovered at E3.5-4.0. Null blastocysts failed to hatch or attach in vitro, indicating a trophectoderm defect, although the inner cell mass could grow in culture. Of note, Mcl-1(-/-) blastocysts showed no evidence of increased apoptosis, but exhibited a delay in maturation beyond the precompaction stage. This model indicates that Mcl-1 is essential for preimplantation development and implantation, and suggests that it has a function beyond regulating apoptosis. |
