| First Author | Ekholm-Reed S | Year | 2019 |
| Journal | Commun Biol | Volume | 2 |
| Pages | 125 | PubMed ID | 30963113 |
| Mgi Jnum | J:278038 | Mgi Id | MGI:6356095 |
| Doi | 10.1038/s42003-019-0366-x | Citation | Ekholm-Reed S, et al. (2019) Reducing Mcl-1 gene dosage induces dopaminergic neuronal loss and motor impairments in Park2 knockout mice. Commun Biol 2:125 |
| abstractText | Mutations in the PARK2 gene are associated with early onset Parkinsonism. The Park2 (-/-) mouse, however, does not exhibit neurodegeneration or other Parkinson's disease (PD) phenotypes. Previously, we discovered that translation of Mcl-1, a pro-survival factor, is upregulated in the Park2 (-/-) mouse, suggesting a compensatory mechanism during development. Here we generated the Park2 (-/-) Mcl-1 (+/-) mouse and show that by reducing Mcl-1 gene dosage by 50%, the Park2 (-/-) genotype is sensitized, conferring both dopaminergic neuron loss and motor impairments. We propose that this murine model could be a useful tool for dissecting PD etiology and developing treatment strategies against this neurodegenerative disease. |
